Thermo Fisher Scientific SURF1 Polyclonal Antibody
SURF1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로 인간, 마우스, 랫트 반응성. Western blot 검증 완료. 항원 친화 크로마토그래피로 정제된 액상 형태이며, PBS buffer에 글리세롤 포함. 연구용으로만 사용 가능.
- 카탈로그번호
- PA549828
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific SURF1 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:3,000
Publications: - [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from internal region of human SURF1 (UniProt ID: Q15526-1, antigen range: 171–198) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2635281 |
Product Specific Information
The antibody detects endogenous levels of total SURF-1 protein.
Target Information
The SURF-1 protein plays a crucial role in the assembly of complex IV (CIV or COX) of the mitochondrial respiratory chain. It is expressed in the inner mitochondrial membrane. Mutations in the SURF-1 gene generally cause cytochrome c oxidase complex IV deficiency, leading to Leigh syndrome—a severe neurological disorder characterized by necrotic lesions in subcortical brain regions.
SURF-1 mutations are associated with high post-implantation embryonic lethality and early-onset mortality. Deficits in muscle strength and motor performance are notable defects of SURF-1 activity, particularly in skeletal muscle and liver. Morphological abnormalities in heart, brain, and skeletal muscle frequently occur due to SURF-1 mutations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-49828_SURF1_Q15526-1_Rabbit.svg, PA5-49828_SURF1_Q15526-1_Rabbit_PDP.jpeg)
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