Thermo Fisher Scientific WTAP Polyclonal Antibody
Rabbit polyclonal antibody recognizing human WTAP protein. Validated for Western blot (1:500–1:3,000). Detects endogenous WTAP involved in mRNA splicing regulation. Supplied as liquid, 1 mg/mL, stored at -20°C. For research use only.
- 카탈로그번호
- PA549827
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from C-terminal of human WTAP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635280 |
Product Specific Information
This antibody detects endogenous levels of total WTAP protein.
Target Information
Wilms’ tumor (WT) is an embryonal malignancy of the kidney that affects approximately 1 in 10,000 infants and occurs in both sporadic and inherited forms. The Wilms tumor protein (WT1) binds the DNA sequence GCGGGGGCG, a recognition element shared with the Egr family of Zn²⁺ finger transcriptional activators, functioning as a transcriptional repressor.
WTAP (Wilms tumor 1-associating protein) is a ubiquitously expressed nuclear protein that interacts with WT1 and may regulate mRNA splicing. It localizes to nuclear speckles and controls the G2/M cell cycle transition by binding to the 3′ UTR of cyclin A2 mRNA, enhancing its stability. WTAP also inhibits expression of WT1 target genes and reduces WT1 DNA-binding ability. Two isoforms of WTAP exist due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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