Thermo Fisher Scientific APC7 Polyclonal Antibody
APC7 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC에 적합합니다. 인간, 마우스, 랫트에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 1 mg/mL 농도, PBS 버퍼 및 sodium azide 포함. 세포주기 조절 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (IHC) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide near the carboxy terminus of human APC7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152039 |
Product Specific Information
- Suggested positive control: rat kidney tissue lysate
- PA5-20948 can be used with blocking peptide PEP-1062.
Target Information
Cell cycle regulated protein ubiquitination and degradation within subcellular domains is essential for normal mitotic progression.
APC7 is a conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase controlling mitosis and G1 phase progression.
APC/C degrades anaphase inhibitors, mitotic cyclins, and spindle-associated proteins to ensure proper mitotic sequence.
APC7 facilitates protein ubiquitination and interaction of APC/C with transcription coactivators.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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