Thermo Fisher Scientific SIK2 Polyclonal Antibody
Thermo Fisher Scientific의 SIK2 Polyclonal Antibody는 인간, 마우스, 랫트 시료에서 SIK2 단백질을 검출하는 고품질 항체입니다. Western blot 및 면역세포화학(ICC/IF)에 적합하며, 고순도 친화성 정제 방식으로 생산되었습니다. 연구용 전용 제품입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SIK2 (Accession Q9H0K1), corresponding to amino acid residues Y517–S567 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853605 |
Product Specific Information
This antibody detects endogenous levels of total SIK2.
Target Information
SNF1LK2 (QIK) is a serine/threonine kinase belonging to the AMP-activated protein kinase family. It negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator TORC.
SIK2 is involved in signaling cascades that regulate insulin-induced genes such as PGC-1α and UCP-1 in brown adipocytes, with implications in obesity and insulin resistance.
Additionally, SIK2 acts as a key regulator of neuronal survival after ischemia, suppressing CREB-mediated gene expression following oxygen-glucose deprivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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