Thermo Fisher Scientific Human IL-33 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 19 amino acids near the center of human IL-33.
PEP-0515 can be used as a blocking peptide with polyclonal antibody PA5-20398.

Target Information

IL-33 (Interleukin-33) is a 270 amino acid, highly divergent protein belonging to the IL-1 family with an IL-1-like C-terminal domain. IL-33 functions as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. It binds to and signals through IL1RL1/ST2, recruiting MYD88, IRAK1, IRAK4, and TRAF6, thereby activating NF-kappaB and MAP kinases. This leads to the production of TH2-associated cytokines such as IL-4, IL-5, and IL-13, causing pathological changes in mucosal organs. IL-33 is proteolytically converted to a mature form by CASP1 and is highly expressed in high endothelial venules of tonsils, Peyer’s patches, and mesenteric lymph nodes, but is almost undetectable in placenta. Prolonged IL-33 treatment in mice induces eosinophilia, splenomegaly, and severe mucosal organ pathology. IL-33 can co-localize with heterochromatin and has transcriptional repressor activities, supporting its dual role as a cytokine and nuclear factor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.