Thermo Fisher Scientific Human ADAP Synthetic Peptide
인간 ADAP 단백질의 N-말단 17개 아미노산 서열에 해당하는 합성 펩타이드입니다. ADAP 항체(PA5-20401)와 함께 블로킹 실험에 사용됩니다. 정제된 액상 형태로 제공되며, PBS 버퍼(pH 7.2, 0.1% BSA)와 sodium azide를 포함합니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PEP0518
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 17 amino acids near the amino terminus of human ADAP.
PEP-0518 can be used as a blocking peptide with polyclonal antibody PA5-20401.
Target Information
The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion.
TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kappa-B family of transcription factors.
More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell-antigen presenting cell (APC) activation.
At least three isoforms of ADAP are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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