Thermo Fisher Scientific KCNN2 Polyclonal Antibody
KCNN2 단백질을 타겟으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC에 적합합니다. 인간 시료 반응성이 있으며, 동결건조 형태로 제공됩니다. 신경세포 흥분성 조절 연구용으로 적합한 연구 전용 시약입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:300–1:2,000
Immunohistochemistry (IHC)
- Tested Dilution: 1:300–1:2,000
Miscellaneous PubMed (Misc)
- Publications: View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the C-terminal region of human KCNN2 (SK2) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: KCNN2.
Target Information
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and significantly affect neuronal firing patterns.
Each component of the AHP is kinetically distinct and mediated by different calcium-activated potassium channels.
The KCNN2-encoded protein is activated before membrane hyperpolarization and regulates neuronal excitability by contributing to the slow component of synaptic AHP.
It forms a voltage-independent, calcium-activated channel with three calmodulin-binding subunits and belongs to the KCNN family of potassium channel genes.
Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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