Thermo Fisher Scientific KLF4 Polyclonal Antibody

Thermo Fisher Scientific KLF4 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid repeated freeze/thaw cycles.
• Centrifuge product if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.
• This affinity purified antibody is directed against human KLF4.
• Blast analysis shows 100% identity with human and 93% identity with mouse sequences.

Target Information

Kruppel-like factor 4 (KLF4) protein is encoded by the KLF4 gene located on chromosome 9 in humans. Also known as gut-enriched Kruppel-like factor (GKLF) or epithelial zinc-finger protein (EZF), it belongs to the Kruppel-like family of DNA-binding zinc finger transcription factors.
KLF4 is one of the four Yamanaka factors, playing a key role in reprogramming differentiated cells into pluripotent stem cells. It is involved in endothelial cell signaling, adipogenesis, differentiation, embryogenesis, and cell cycle control.
Nuclear localization is associated with oncogenic function, while cytosolic localization relates to tumor suppression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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