Thermo Fisher Scientific CD11b Recombinant Rabbit Monoclonal Antibody (JU93-81)
Thermo Fisher Scientific의 CD11b Recombinant Rabbit Monoclonal Antibody (JU93-81)는 인간 CD11b 단백질을 타겟으로 하는 고특이성 항체입니다. Western Blot, IHC, ICC/IF에 사용 가능하며, 로트 간 일관성과 높은 감도를 제공합니다. 연구용으로 적합한 고순도 단백질 A 정제 항체입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:800 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JU93-81 |
| Immunogen | Synthetic peptide within Human CD11b (amino acids 1103–1152) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2810069 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening to select the best candidates for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the larger rabbit immune repertoire
Target Information
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18).
The CD11b/CD18 complex (Mac-1, CR3) functions as a receptor for ICAM-1, ICAM-2, ICAM-4, CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X—critical for cell-cell and cell-matrix interactions.
CD11b is expressed on:
- Monocytes/macrophages
- Granulocytes
- Activated lymphocytes
- NK cell subsets
- Dendritic cells
- Microglia
Expression levels vary among tissues and increase during monocyte maturation. It is a common microglial marker and is expressed on:
- 8% of spleen cells
- 44% of bone marrow cells
- <1% of thymocytes
Diseases associated with CD11b dysfunction include systemic lupus erythematosus and ITGAM-related susceptibility to lupus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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