Thermo Fisher Scientific MMP-2 Polyclonal Antibody
Human MMP-2 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 적용 가능. Antigen affinity chromatography로 정제되었으며, 0.5 mg/mL 농도의 액상 형태. 세포 내 및 ECM 내 존재하는 MMP-2 검출에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 0.1–1 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to C-terminal region of human MMP2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C (short term); -20°C (long term), avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Breast cancer
- Cellular location: Cytoplasmic and extracellular matrix
Target Information
Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade connective tissue components. They share a conserved metal-binding active site and are inhibited by tissue inhibitors of metalloproteinases (TIMPs). MMPs and TIMPs regulate angiogenesis.
MMP-2 is synthesized as a 631 amino acid proenzyme activated by cleavage of the first 80 amino acids. It includes propeptide, catalytic, and hemopexin domains. MMPs collectively degrade extracellular matrix components such as collagens, fibronectin, laminin, and basement membrane glycoproteins. Structurally, MMPs possess a signal peptide, propeptide, and catalytic domain with a conserved zinc-binding site.
Functionally, MMP-2 is involved in tissue remodeling. Mutations in the MMP-2 gene are associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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