Thermo Fisher Scientific HOXB4 Polyclonal Antibody
HOXB4 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC(P), ICC/IF에 적합합니다. 인간 및 생쥐 시료에 반응하며, PBS/glycerol 용액 형태로 제공됩니다. 줄기세포 및 조혈 분화 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human HOXB4 (Accession P17483), corresponding to amino acid residues S4–F54 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852510 |
Product Specific Information
This antibody detects endogenous levels of total HOXB4.
Target Information
HOX homeobox genes play a role both in early stem cell function and in later stages of hematopoietic differentiation.
HOXB4 is a homeotic selector gene implicated in self-renewal of definitive hematopoietic stem cells (HSCs). Expression of HOXB4 in primitive progenitors, combined with culture on hematopoietic stroma, induces a switch to the definitive HSC phenotype.
Activation of WNT signaling in HSCs increases expression of HOXB4. Perturbations of HOX gene expression can cause leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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