Thermo Fisher Scientific LSD1 Polyclonal Antibody
LSD1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체입니다. Western blot에 적합하며 인간 및 설치류 반응성이 확인되었습니다. 고순도 항원 친화 크로마토그래피 정제, 액상 형태로 제공되며 장기 보관 시 -20°C에서 안정적입니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific LSD1 Polyclonal Antibody
Thermo Fisher Scientific LSD1 Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:3,000
Species Reactivity
- Human
- Rat
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human LSD1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.59 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792566 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (91%), Pig (99%), Rhesus Monkey (100%).
- Positive Control: NT2D1, IMR32, MCF-7, PC-12, Rat2.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
LSD1 is a histone demethylase that specifically demethylates Lys-4 of histone H3, a tag for epigenetic transcriptional activation, acting as a corepressor. It contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. LSD1 is part of histone deacetylase complexes and silences genes by demethylation. It oxidizes substrates via FAD to generate imine intermediates that are hydrolyzed. LSD1 demethylates mono- and tri-methylated Lys-4 of histone H3 and may repress neuronal genes. It requires RCOR1/CoREST for nucleosome demethylation and may also demethylate Lys-9 of histone H3, leading to derepression of androgen receptor target genes. Mutations in LSD1 can cause cleft palate, psychomotor retardation, and distinctive facial features.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.