Thermo Fisher Scientific Nicastrin Polyclonal Antibody
Rabbit polyclonal antibody recognizing human Nicastrin; validated for WB and ICC/IF; suitable for multiple species; supplied as liquid, 1 mg/mL; for research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human Nicastrin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4 °C short term. For long-term storage, store at −20 °C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792567 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (92%), Rat (92%), Dog (94%), Rhesus Monkey (100%), Bovine (89%).
- Positive control: 293T, HeLa, HepG2.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
NCSTN (Nicastrin) encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. This protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of neuritic plaques characteristic of Alzheimer’s disease. The exact role of this protein in Alzheimer’s disease remains unclear. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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