Thermo Fisher Scientific Phospho-IRAK4 (Thr345) Monoclonal Antibody (A8A8)
IRAK4 단백질의 Thr345 인산화 부위를 인식하는 단클론 항체. Western blot 및 IHC(P) 분석에 적합하며, 다양한 종(인간, 마우스 등)에 반응. 단백질 A로 정제된 액상 항체로, 4°C 단기 보관 및 -20°C 장기 보관 권장.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Dog, Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A8A8 |
| Immunogen | Synthetic peptide surrounding the epitope -VMTSR- with phosphorylation site at Thr345 of human IRAK4 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | 25 mM Tris with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Jurkat cell lysate
- Cellular location: Cytoplasmic
Target Information
IL-1 receptor-associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. Overexpression of IRAK4 activates NF-kappa-B and MAPK pathways. IRAK4 interacts with and phosphorylates IRAK1.
IRAK4-deficient animals are resistant to LPS challenge, and both animals and humans lacking IRAK4 show impaired responses to viral and bacterial infections. Members of the IRAK/Pelle family play a central role in IL-1R/TLR-mediated inflammatory responses and innate immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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