Thermo Fisher Scientific A2M Polyclonal Antibody
Human A2M 단백질을 인식하는 Thermo Fisher Scientific의 Goat Polyclonal Antibody로, WB 및 IHC(P) 응용에 적합합니다. 고순도(Ammonium sulfate precipitation)로 정제되었으며, 안정적인 액상 형태로 -20°C 보관이 권장됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-TSLTVRVNYKDRSP (aa 417–430) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933775 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
Alpha 2-Macroglobulin (A2M) is an approximately 720-kDa homotetrameric glycoprotein composed of four identical ~180 kDa subunits. A2M shares with other alpha-macroglobulins, such as complement components C3, C4, and pregnancy zone protein (PZP), a broad binding capacity for diverse ligands. This enables alpha-macroglobulins to act as humoral defense barriers against foreign peptides in plasma. A2M interacts with and captures virtually any proteinase, functioning as a panprotease inhibitor. In Alzheimer’s disease (AD) patients, A2M has been localized to diffuse amyloid plaques, suggesting an important role in AD etiopathology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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