Thermo Fisher Scientific Complement C9 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1–3 µg/mL
• Publications: [References not provided]

Product Specifications

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:4,000.

Target Information

C5b-9 membrane attack complexes are assembled from five precursor molecules in the serum. Proteolytic cleavage of C5 by C5 convertase generates C5b which initiates assembly of the C5b-9 complex. The last step of C5b-9 complex formation involves polymerization of C9, which accompanies insertion of the complex into the cell membrane. During formation of C5b-8 and C9 polymerization, neoantigens are generated that are unique to the C5b-9 complex and are not present on any of the individual native complex components. Complement regulatory proteins CD59 and complement S-protein can both prevent C5b-9 insertion into the cell membrane. The formed SC5b-9 complex is unable to attach to cells and is cytolytically inactive. C5b-9 is involved in the progression of chronic proteinuric renal disease by mediating continuous tubulointerstitial damage. Early tubulointerstitial injury in the remnant kidney can be improved when C5b-9 complex formation is abrogated.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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