Thermo Fisher Scientific CD38 (ADP Ribosyl Cyclase I) Monoclonal Antibody (AT2)
인간 CD38 단백질을 인식하는 Mouse 모노클로날 항체로, ICC/IF 및 유세포분석(Flow Cytometry)에 사용 가능. 단백질 A/G로 정제된 액상 항체이며, 4°C 보관. 림프구 활성화 및 백혈병 연구용으로 적합.
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Applications
Immunocytochemistry (ICC/IF)
- Assay-dependent
Flow Cytometry (Flow)
- 1–2 µg/10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG3, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AT2 |
| Immunogen | Human T cell line CCRF-CEM |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD38 (NAD⁺ glycohydrolase) is a type II transmembrane glycoprotein that induces activation, proliferation, and differentiation of mature lymphocytes, and mediates apoptosis of myeloid and lymphoid progenitor cells.
It functions as a multi-catalytic ectoenzyme with ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, and possibly NAD⁺ glycohydrolase activity, or as a cell surface receptor.
Antibodies to CD38 are useful for:
- Subtyping lymphomas and leukemias
- Detection of plasma cells (e.g., myeloma identification)
- Marker for activated B and T cells
CD38 is involved in cell adhesion, signal transduction, and calcium signaling, and is highly expressed in the pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter’s Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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