Thermo Fisher Scientific CD38 (ADP Ribosyl Cyclase I) Monoclonal Antibody (AT1)
인간 CD38 단백질을 인식하는 마우스 단클론 항체로, ADP Ribosyl Cyclase I 연구에 적합합니다. ICC/IF 및 유세포분석(Flow Cytometry)에 사용 가능하며, Protein A/G로 정제된 액상 형태입니다. 보존제 없이 PBS(pH 7.4)에 용해되어 있으며, -20°C 이하에서 보관합니다.
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Applications and Tested Dilutions
Immunocytochemistry (ICC/IF)
- Recommended dilution: 1–2 µg/10⁶ cells
Flow Cytometry (Flow)
- Recommended dilution: 1–2 µg/10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AT1 |
| Immunogen | Human T cell line CCRF-CEM |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD38 (NAD⁺ glycohydrolase) is a type II transmembrane glycoprotein that induces activation, proliferation, and differentiation of mature lymphocytes and mediates apoptosis of myeloid and lymphoid progenitor cells.
It functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, and possibly NAD⁺ glycohydrolase, or as a cell surface receptor.
Antibodies to CD38 are useful for:
- Subtyping of lymphomas and leukemias
- Detection of plasma cells (e.g., identification of myelomas)
- Marking activated B and T cells
CD38 is involved in cell adhesion, signal transduction, and calcium signaling, and is highly expressed in the pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter’s syndrome.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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