Thermo Fisher Scientific CD38 (ADP Ribosyl Cyclase I) Monoclonal Antibody (CD38, 4328)
CD38 단백질을 인식하는 Mouse Monoclonal Antibody로, Western blot, IHC, ICC, Flow Cytometry 등에 사용 가능. 인간 CD38 단백질에 특이적이며 Protein A/G로 정제됨. PBS 버퍼에 보관되며 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/10⁶ cells |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CD38, 4328 |
| Immunogen | Recombinant full-length human CD38 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
CD38 (NAD⁺ glycohydrolase) is a type II transmembrane glycoprotein that induces activation, proliferation, and differentiation of mature lymphocytes and mediates apoptosis of myeloid and lymphoid progenitor cells.
It functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, and possibly NAD⁺ glycohydrolase, or as a cell surface receptor.
Antibodies to CD38 are useful for:
- Subtyping of lymphomas and leukemias
- Detection of plasma cells (e.g., myeloma identification)
- Marker for activated B and T cells
CD38 participates in cell adhesion, signal transduction, and calcium signaling. It is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter’s Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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