Thermo Fisher Scientific RGMA Polyclonal Antibody
Thermo Fisher Scientific RGMA Polyclonal Antibody는 인간, 마우스, 랫트에서 RGMA 단백질을 검출하는 다클론 항체입니다. Western blot 및 면역세포염색(ICC/IF)에 적합하며, 액상 형태로 제공됩니다. 고순도 친화 크로마토그래피 정제, 안정적인 PBS/글리세롤 저장용액 포함.
- 카탈로그번호
- PA5115836
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RGMA (Accession Q96B86), corresponding to amino acid residues D228–G278 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900470 |
Product Specific Information
Antibody detects endogenous levels of total Repulsive Guidance Molecule A (RGMA).
Target Information
RGMA is a member of the repulsive guidance molecule (RGM) family, functioning in both developing and adult nervous systems. It regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and contributes to mature synapse formation. Binding to its receptor NEO1/neogenin activates the RHOA-ROCK1/Rho-kinase signaling pathway via UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to neuronal growth cone collapse and neurite inhibition. RGMA-NEO1 interaction also influences HRAS-PTK2/FAK1-AKT1 signaling, resulting in HRAS inactivation. Additionally, RGMA functions as a BMP coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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