Thermo Fisher Scientific RB1 Polyclonal Antibody
RB1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot에 적합합니다. 인간, 마우스, 랫트, 비인간 영장류에 반응하며, 친화 크로마토그래피로 정제되었습니다. PBS/50% 글리세롤 완충액에 1 mg/mL 농도로 제공됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RB1 (Accession P06400), corresponding to amino acid residues G801–M851 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900472 |
Product Specific Information
This antibody detects endogenous levels of total Retinoblastoma (Rb) protein.
Target Information
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine residues, but not on tyrosine. It forms complexes with SV40 large T antigen, adenovirus E1A, and human papillomavirus-16 E. Rb protein may regulate transcription, and loss of its function can lead to uncontrolled cell growth. Mutations or aberrations in the RB gene are associated with various cancers, including breast, colon, prostate, kidney, nasopharyngeal cancers, and leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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