Thermo Fisher Scientific PGP9.5 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Immunohistochemistry (IHC)

• Tested Dilution: 1:100–1:500

Product Specifications

Target Information

PGP9.5 (Protein Gene Product 9.5, UCH-L1, PARK5) is a neuron-specific protein, structurally and immunologically distinct from neuron-specific enolase. It has a molecular weight of 27 kDa and belongs to the ubiquitin carboxyl-terminal hydrolase family 1 (peptidase family C12). PGP9.5 possesses ubiquitin hydrolase and ligase activities, hydrolyzing small C-terminal adducts of ubiquitin to generate ubiquitin monomers.

PGP9.5 is expressed in neurons and nerve fibers throughout the central and peripheral nervous system, in neuroendocrine cells, renal tubule segments, spermatogonia, Leydig cells of the testis, ova, and corpus luteum cells. Overexpression is associated with non-small cell lung cancer, while decreased expression is linked to Huntington and Alzheimer diseases. Due to its presence in neuronal inclusions, PGP9.5 serves as a useful neuronal marker and is valuable for studies of neurodegenerative disorders such as Parkinson’s disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.