Thermo Fisher Scientific VR1 N-Terminus (TRPV1) Polyclonal Antibody
TRPV1 단백질의 N-말단을 인식하는 토끼 폴리클로날 항체로, WB, IHC, ICC/IF에 사용 가능. 캡사이신 수용체 연구 및 통증 관련 신호전달 연구에 적합. 액상 형태로 제공되며 -20°C에서 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (IHC) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | RASLDSEESESPPQENSC |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons.
TRPV1 is a non-selective cation channel related to TRP family members such as TRPC3 and TRPC6, permeable to calcium, magnesium, and monovalent cations (sodium, potassium).
It contains 6 transmembrane domains, a P-loop membrane domain, and 3 ankyrin repeat domains. TRPV1 is activated by noxious heat, functioning as a transducer of painful thermal stimuli. It may mediate proton influx and contribute to intracellular acidosis in nociceptive neurons. Expression is mainly in sensory ganglia neurons.
Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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