Thermo Fisher Scientific P2X2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

P2rx2 belongs to the ligand-gated ion channel family that opens in response to extracellular ATP. Each receptor consists of a trimer of subunits (P2X1–7), sharing a common structure with two transmembrane domains. P2rx2 mediates synaptic transmission between neurons and from neurons to smooth muscle by binding ATP.

Six transcript variants encoding distinct isoforms have been identified for P2rx2. It is involved in various cellular responses, including excitatory postsynaptic signaling in sensory neurons, neuromuscular junction formation, hearing, taste perception, and peristalsis. In the inner ear, P2rx2 regulates sound transduction, auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and potassium recycling.

Diseases associated with P2RX2 include Autosomal Dominant Deafness 41 and DFNA41 Nonsyndromic Hearing Loss and Deafness.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.