Thermo Fisher Scientific MYPT1 Polyclonal Antibody
Rabbit polyclonal antibody against MYPT1 for Western blot applications. Reacts with human, mouse, rat, hamster, and primate samples. Supplied as a liquid, unconjugated form at 5 µg/mL. Stored at -20°C in HEPES buffer with BSA and glycerol. For research...
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Applications
Western Blot (WB)
- Tested dilution: 1:1,000
- View 3 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Hamster, Human, Mouse, Non-human primate, Rat |
| Published Species | Human, Pig |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino-terminal residues of human MYPT1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 5 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10978517 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other family members.
Target Information
Myosin phosphatase target subunit 1 (MYPT1), also known as the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. This enzyme regulates the interaction of actin and myosin downstream of the small GTPase Rho. Active RhoA (GTP-bound form) interacts with the myosin-binding subunit (MBS) of myosin phosphatase, controlling the phosphorylation state of myosin light chain (MLC). Rho-associated kinase (Rho-kinase), activated by GTP·RhoA, phosphorylates MBS, leading to inactivation of myosin phosphatase. Overexpression of RhoA or its active form increases MBS and MLC phosphorylation, indicating that Rho inhibits myosin phosphatase via Rho-kinase. Multiple transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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