Thermo Fisher Scientific Rb Polyclonal Antibody
Rb 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 Immunocytochemistry에 적합합니다. 합성 펩타이드 면역원 기반으로 제작되었으며, 고순도 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 830 to the C-terminus of human Rb (NP_000312.2). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.89 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855687 |
Product Specific Information
Sequence of this protein is as follows:
RILVSIGESF GTSEKFQKIN QMVCNSDRVL KRSAEGSNPP KPLKKLRFDI EGSDEADGSK HLPGESKFQQ KLAEMTSTRT RMQKQKMNDS MDTSNKEEK
Target Information
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription, and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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