Thermo Fisher Scientific RANKL Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000
• View 3 publications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:50–1:200
• View 1 publication

Product Specifications

Product Specific Information

Protein sequence:
RISEDGTHCI YRILRLHENA DFQDTTLESQ DTKLIPDSCR RIKQAFQGAV QKELQHIVGS QHIRAEKAMV DGSWLDLAKR SKLEAQPFAH LTINATDIPS GSHKVSLSSW YHDRGWAKIS NMTFSNGKLI VNQDGFYYLY ANICFRHHET SGDLATEYLQ LMVYVTKTSI KIPSSHTLMK GGSTKYWSGN SEFHFYSINV GGFFKLRSGE EISIEVSNPS LLDPDQDATY FGAFKVRDID

Target Information

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation.
It acts as a dendritic cell survival factor and regulates T cell–dependent immune responses.
T cell activation induces expression of this gene, leading to increased osteoclastogenesis and bone loss.
It activates antiapoptotic kinase AKT/PKB through a complex involving SRC kinase and TRAF6, suggesting a role in apoptosis regulation.
Gene disruption in mice results in severe osteopetrosis, lack of osteoclasts, and defects in T/B lymphocyte differentiation and mammary gland development.
Two alternatively spliced transcript variants have been identified.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.