Thermo Fisher Scientific p300 Polyclonal Antibody
Thermo Fisher Scientific의 p300 Polyclonal Antibody는 인간 p300 단백질을 특이적으로 인식하는 토끼 유래 다클론 항체입니다. Western blot, ChIP, ICC/IF에 적합하며 고순도의 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 2 publications |
| Immunocytochemistry (ICC/IF) | 5 µg/mL | - |
| ChIP assay (ChIP) | 2.5 µg/10^6 cells | View 3 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues G(139) T S G P N Q G P T Q S T(151) C in the nuclear factor binding domain of human p300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_325902 |
Product Specific Information
PA1-848 detects p300 from human cells.
This antibody has been successfully used in Western blot and ChIP procedures.
By Western blot, PA1-848 detects an approximately 265 kDa protein representing p300 from HeLa cell lysate.
The immunogen is a synthetic peptide corresponding to residues G(139) T S G P N Q G P T Q S T(151) C in the nuclear factor binding domain of human p300.
The immunizing peptide (Cat. # PEP-053) is available for use in neutralization and control experiments.
Target Information
EP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein.
p300 is related by sequence to CPB (CREB-binding protein), and like CPB, can stimulate transcription through activation of CREB.
This EP300 activity is specifically inhibited by the adenovirus oncoprotein E1A.
EP300 also acts as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), playing a role in the stimulation of hypoxia-induced genes such as VEGF.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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