Thermo Fisher Scientific ABHD13 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
MRYLPLWCYK NKFLSYRKIS QCRMPSLFIS GLSDQLIPPV MMKQLYELSP SRTKRLAIFP DGTHNDTWQC QGYFTALEQF IKEVVK

Highest antigen sequence identity:

• Mouse: 99%
• Rat: 99%

Target Information

The α/β hydrolase superfamily includes diverse members involved in critical biochemical processes and various diseases. Despite differences in sequence and substrate specificity, they share a canonical α/β hydrolase fold with an eight-stranded parallel α/β structure and a catalytic triad composed of histidine, an acid, and a nucleophile.

Members of this superfamily are potential drug targets for diseases such as diabetes, Alzheimer’s disease, obesity, and blood clotting disorders. The ABHD gene subfamily includes 15 members, most of which utilize a serine nucleophile forming the G-X-S-X-G motif.

• ABHD1: Metabolizes smoking xenobiotics
• ABHD2: Involved in atherosclerosis development
• ABHD4: Participates in alternative NAE synthesis pathway
• ABHD5: Mutations cause Chanarin-Dorfman syndrome
• ABHD6: May play a role in nervous system metabolism and signaling
• ABHD13: 337 amino acid single-pass membrane protein belonging to the ABHD family

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.