Thermo Fisher Scientific ABHD13 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
KSEGEASEEG LYLDSEAVLD YVMTRPDLDK TKIFLFGRSL GGAVAIHLAS ENSHRISAIM VENTFLSIPH MASTLFSFFP

Highest antigen sequence identity to the following orthologs:

• Mouse: 99%
• Rat: 99%

Target Information

The α/β hydrolase superfamily comprises diverse members involved in important biochemical processes and various diseases. Despite having unrelated sequences and different catalytic activities, they share the canonical α/β hydrolase fold with an eight-stranded parallel α/β structure and a catalytic triad (histidine, acid, nucleophile).

Members of this superfamily are often drug targets for diseases such as diabetes, Alzheimer’s disease, obesity, and blood clotting disorders. The ABHD gene subfamily includes 15 mostly uncharacterized members, most using a serine nucleophile forming the G-X-S-X-G nucleophile elbow.

• ABHD1: Metabolizes smoking xenobiotics
• ABHD2: Involved in atherosclerosis development
• ABHD4: Participates in alternative NAE synthesis pathway
• ABHD5: Mutations linked to Chanarin-Dorfman syndrome
• ABHD6: May play a role in nervous system metabolism and signaling
• ABHD13: 337 amino acid single-pass membrane protein belonging to the ABHD family

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.