Thermo Fisher Scientific PLEKHM2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PLEKHM2. Recombinant protein control fragment (Product #RP-100983). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PLEKHM2,uniProtId:Q8IWE5-1,ncbiNodeId:9606,antigenRange:545-663,antigenLength:1019,antigenImageFileName:PA5-56946_PLEKHM2_Q8IWE5-1_Rabbit.svg,antigenImageFileNamePDP:PA5-56946_PLEKHM2_Q8IWE5-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2645667

Product Specific Information

Immunogen sequence: GTQEVLCQLK RDQPSPCLSS AEDSGVDEGQ GSPSEMVHSS EFRVDNNHLL LLMIHVFREN EEQLFKMIRM STGHMEGNLQ LLYVLLTDCY VYLLRKGATE KPYLVEEAVS YNELDYVSV

Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 96%.

Target Information

PLEKHM2, also known as SKIP, is a member of the M family of Pleckstrin homology domain-containing proteins. While little is known of PLEKHM2, a recent study examining differential gene expression in human hematopoietic stem cells has shown it to be specifically expressed in stem cells, suggesting that PLEKHM2 may play a role in erythroid commitment and development. Other studies have shown that PLEKHM2 is required for interaction with the Salmonella virulence factor SifA for Salmonella pathogenesis, suggesting that PLEKHM2 has cellular roles other than in the developing embryo.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.