Thermo Fisher Scientific F10 Monoclonal Antibody (OTI1D12), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Factor X undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by excision of the tripeptide RKR. The two chains are linked by disulfide bonds; the light chain contains two EGF-like domains, while the heavy chain includes the catalytic domain homologous to other hemostatic serine proteases. Activation occurs via cleavage by factor IXa (intrinsic pathway) or factor VIIa (extrinsic pathway), converting prothrombin to thrombin in the presence of factor Va, Ca²⁺, and phospholipid during blood clotting.
Mutations in this gene cause factor X deficiency, a hemorrhagic disorder of variable severity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.