Thermo Fisher Scientific CD30 Monoclonal Antibody (HRS4)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA5-12532 targets CD30 in IHC (P) applications and shows reactivity with Human samples.
The immunogen used is the recombinant extracellular domain of CD30 protein.

Target Information

CD30 (Ki-1, TNF Receptor Superfamily Member 8) is a type I transmembrane glycoprotein belonging to the TNF receptor superfamily.
Originally identified as a surface antigen of Hodgkin’s and Reed-Sternberg cells using monoclonal antibody Ki-1, CD30 binds to its ligand CD30L (CD153) to mediate various biological effects such as proliferation, activation, differentiation, and apoptosis.

CD30 plays a critical role in:

• Pathophysiology of Hodgkin’s disease and other CD30+ lymphomas
• Thymic negative selection as a costimulatory molecule
• Expression in Hodgkin’s and Reed-Sternberg cells, non-Hodgkin’s lymphomas, virus-infected T/B cells, and activated normal T/B cells

Additionally:

• CD30 expression is found in T cells producing Th2-type cytokines
• Soluble CD30 (sCD30) serves as a marker of Th2 immune response
• TRAF2 and TRAF5 interact with CD30 to activate NF-κB signaling
• CD30 acts as a positive regulator of apoptosis, limiting autoreactive CD8 T cell proliferation and protecting against autoimmunity

Two alternatively spliced transcript variants encoding distinct isoforms have been reported.

CD30 is expressed by:

• Mononuclear cells in Hodgkin’s lymphoma
• Reed-Sternberg cells
• Most Anaplastic Large Cell Lymphomas (ALCL)
• Embryonal carcinomas

For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.