Thermo Fisher Scientific ABCB1 Monoclonal Antibody (OTI2G1), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The ABCB1 gene encodes a membrane-associated protein belonging to the ATP-binding cassette (ABC) transporter superfamily.
These proteins transport diverse molecules across cellular membranes and are categorized into seven subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
ABCB1, part of the MDR/TAP subfamily, functions as an ATP-dependent drug efflux pump with broad substrate specificity, contributing to multidrug resistance by decreasing intracellular drug accumulation.
It also plays a role in the blood-brain barrier as a transporter.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.