Thermo Fisher Scientific ABCB1 Monoclonal Antibody (OTI2G1), TrueMAB
ABCB1 단백질을 인식하는 마우스 모노클로날 항체로, Western blot 및 IHC(P) 분석에 적합합니다. 인간 시료에 반응하며, 동결건조 형태로 제공됩니다. 재구성 후 1 mg/mL 농도로 사용 가능하며, 약물 내성 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2G1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 995–1280 of human ABCB1 produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The ABCB1 gene encodes a membrane-associated protein belonging to the ATP-binding cassette (ABC) transporter superfamily.
These proteins transport diverse molecules across cellular membranes and are categorized into seven subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
ABCB1, part of the MDR/TAP subfamily, functions as an ATP-dependent drug efflux pump with broad substrate specificity, contributing to multidrug resistance by decreasing intracellular drug accumulation.
It also plays a role in the blood-brain barrier as a transporter.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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