Thermo Fisher Scientific MMP19 Polyclonal Antibody
Thermo Fisher Scientific의 MMP19 Polyclonal Antibody는 인간 MMP19 단백질을 인식하는 토끼 유래 IgG 항체입니다. Western blot 및 면역세포염색(ICC/IF)에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MMP19. Recombinant protein control fragment (Product # RP-105511) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2857074 |
Product Specific Information
Immunogen sequence:
PVDYLSQYGY LQKPLEGSNN FKPEDITEAL RAFQEASELP VSGQLDDATR ARMRQPRCGL EDPFNQKTLK YLLLGRWRKK HLTFRILNL
Target Information
MMP-19 (also known as RASI-1, MMP-18) is a 508 amino acid peptide originally isolated as an autoantigen from the synovium of a patient with rheumatoid arthritis (RA). Its presence on activated PBMCs, TH1 lymphocytes, and Jurkat T lymphoma cells in RA synovium suggests a role in RA-associated joint tissue destruction.
MMP-19 is expressed in smooth muscle cells of the tunica media of large blood vessels in RA patients, but not in the endothelial cell layer. Acutely inflamed synovial capillaries strongly express MMP-19 in the cytoplasm. Regulated induction of MMP-19 in endothelial cells during acute inflammation suggests a role in angiogenesis.
MMP-19 is a single 2.7 kb transcript found in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis, colon, and heart.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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