Thermo Fisher Scientific ULBP1 Polyclonal Antibody
ULBP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 시료에 반응하며 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 4°C 또는 -20°C에서 안정적 보관. 연구용으로만 사용.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein corresponding to Human ULBP1 (Control fragment: Product #RP-107786) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.30 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2857077 |
Product Specific Information
Immunogen sequence:
WTALHPGAKK MTEKWEKNRD VTMFFQKISL GDCKMWLEEF LMYWEQMLDP TKPPSLAPGT TQPK
Target Information
ULBP1 is the ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3.
ULBPs activate multiple signaling pathways in primary NK cells, resulting in cytokine and chemokine production.
Binding of ULBP ligands to NKG2D induces calcium mobilization and activation of JAK2, STAT5, ERK, and PI3K/Akt pathways.
In CMV-infected cells, ULBP1 interacts with soluble CMV glycoprotein UL16.
This interaction blocks NKG2D binding, allowing CMV-infected cells to evade immune detection.
UL16 also retains ULBP1 in the ER and cis-Golgi, preventing its surface expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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