Thermo Fisher Scientific MUC4 Polyclonal Antibody
MUC4 단백질을 표적하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. 인간 및 랫트 반응성. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제됨. 점막 보호 및 암 관련 MUC4 연구용으로 사용.
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Applications
- Western Blot (WB): 0.1–0.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E.coli-derived human MUC4 recombinant protein (Position: M1249–D1444) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 5 mg BSA |
| Contains | 0.05 mg sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2746818 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
Nearly all mucosal surfaces are protected by mucin transmembrane glycoproteins, from bronchioles to corneas to reproductive tracts.
Mucin 4 (MUC4) is membrane-bound and plays a crucial role in protection and lubrication of mucosal surfaces.
Abnormal MUC4 expression has been observed in various carcinomas and sarcomas, including fibromyoxoid sarcoma and pancreatic adenocarcinoma.
Immunohistochemical staining for MUC4 is discussed as a potential biomarker for cancer detection.
MUC4 mutations have been linked to certain diseases in Asian populations such as Taiwanese infertility, endometriosis, and gallstone formation in Chinese men.
Due to its role in mucosal protection, MUC4 dysfunction is implicated in metastatic cancer invasions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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