Thermo Fisher Scientific AIPL1 Monoclonal Antibody (OTI3B4), TrueMAB
AIPL1 단백질을 인식하는 마우스 모노클로날 항체로, Western blot, IHC, ICC/IF, Flow cytometry에 사용 가능. 인간 시료 반응성. Lyophilized 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3B4 |
| Immunogen | Full-length human recombinant AIPL1 protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Aipl1 is a protein associated with Leber congenital amaurosis (LCA), an autosomal recessive disorder linked to abnormal photoreceptor development. It is a tetratricopeptide repeat protein homologous to ARA9, which participates in HSP90-mediated nuclear translocation and activation of the aryl hydrocarbon receptor.
Aipl1 forms part of a chaperone heterocomplex interacting with Hsp90 and Hsp70, and also associates with the cell cycle regulator NUB1. It cooperates with Hsp70 (but not Hsp90) to suppress NUB1 inclusion formation, crucial for normal photoreceptor maturation. Mutations affecting these interactions lead to LCA.
At least three isoforms of Aipl1 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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