Thermo Fisher Scientific PDE6G Monoclonal Antibody (OTI1F3), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The second messengers cAMP and cGMP are key regulatory molecules involved in a wide variety of signal transduction pathways. Their levels are controlled by synthesis via nucleotide cyclases and hydrolysis via cyclic nucleotide phosphodiesterases (PDEs).
PDE6 functions as the effector enzyme in the G protein-mediated signal transduction cascade of the visual system. It consists of multiple subunits: cone-specific catalytic subunit alpha’, rod-specific catalytic subunits alpha and beta, an inhibitory subunit gamma, and a delta subunit of unknown function.
The catalytic core forms alpha’/alpha’ homodimers (cone) or alpha/beta heterodimers (rod). The C-terminus of both catalytic and inhibitory subunits undergoes methylation, myristoylation, and prenylation, which are essential for proper complex assembly and membrane association.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.