Thermo Fisher Scientific Phospho-p130Cas (Tyr165) Polyclonal Antibody
Phospho-p130Cas (Tyr165)에 특이적인 폴리클로날 항체로, 인간·생쥐·랫드 시료에서 인산화된 형태만 검출. Western blot에 적합하며 고순도 정제, 1 mg/mL 농도. PBS/glycerol buffer에 보관하며 -20°C에서 안정적 유지.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BCAR1 (Accession P56945), corresponding to amino acid residues around phosphorylated Tyr165 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816662 |
Product Specific Information
This antibody detects endogenous levels of p130Cas only when phosphorylated at Tyr165.
Target Information
The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signals via v-Crk and v-Src oncoproteins.
It contains a Src homology (SH)-3 domain followed by multiple YXXP motifs and a proline-rich region.
p130Cas is involved in various biological processes including:
- Cell adhesion and migration
- Growth factor stimulation
- Cytokine receptor engagement
- Bacterial infection
Physiological functions include:
- Cardiovascular development
- Actin filament assembly
- Src-induced cell transformation
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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