Thermo Fisher Scientific Phospho-FOXL2 (Ser238) Polyclonal Antibody
FOXL2 단백질의 Ser238 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. 인간 및 생쥐 반응성. 고순도 액상 형태로 제공되며 -20°C 보관. 연구용 전용 제품.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FOXL2 (Accession P58012), corresponding to amino acid residues around phosphorylated Ser238 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816663 |
Product Specific Information
Antibody detects endogenous levels of FOXL2 only when phosphorylated at Ser238.
Target Information
FOXL2 is a winged helix/forkhead transcription factor highly conserved in human, goat, mouse, and certain aquatic species. It plays a critical role in ovarian differentiation and follicle development. Immunohistochemical data indicate FOXL2 is a nuclear protein expressed in eyelids and ovarian follicular cells. It is associated with blepharophimosis/ptosis/epicanthus inverses syndrome (BPES), which has two forms:
- Type I: eyelid abnormalities with ovarian failure
- Type II: eyelid defects only
FOXL2 expression has been observed in developing mouse eyelid mesenchyme and adult ovarian follicles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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