Thermo Fisher Scientific Phospho-PP2A alpha (Tyr307) Polyclonal Antibody
Phospho-PP2A alpha (Tyr307) 단백질의 인산화 상태를 검출하는 고특이성 폴리클로날 항체. Western blot에 최적화되어 있으며, 인간, 생쥐, 랫드 반응성. 1 mg/mL 농도, -20°C 보관, 연구용 전용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PPP2CA (Accession P67775), corresponding to amino acid residues around phosphorylated Tyr307 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816666 |
Product Specific Information
Antibody detects endogenous levels of PP2A-alpha only when phosphorylated at Tyr307.
Target Information
In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis, and apoptosis.
Protein phosphatases play a critical role in these processes. The protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit, and a catalytic subunit.
Four major families of protein phosphatase catalytic subunits have been identified: PP1, PP2A, PP2B (calcineurin), and PP2C. The PP2A family includes subfamily members PP2A alpha and PP2A beta.
An additional catalytic subunit, PPX (also known as PP4), is considered a putative member of a novel PP family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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