Thermo Fisher Scientific IL1F6 Monoclonal Antibody (OTI3A12), TrueMAB
IL1F6 단백질을 표적하는 Mouse IgG1 단클론 항체로, Western blot 및 Immunocytochemistry에 적합. 인간 반응성으로 높은 특이성과 순도를 보유. Lyophilized 형태로 제공되며, 재구성 및 conjugation 실험에 용이.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3A12 |
| Immunogen | Full length human recombinant protein of human IL1F6 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The IL-1 family includes 11 structurally related ligands, among them IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9).
IL-36α is highly expressed in psoriatic plaques and uniquely expressed by T cells, monocytes, and B cells. It is primarily found in skin and lymphoid tissues, with lower expression in fetal brain, trachea, stomach, and intestine.
IL-36α signals through IL-1Rrp2 (IL-1R6) and IL-RAcP receptors, activating NF-κB and MAPK pathways, and inducing proinflammatory cytokines and chemokines such as IL-6, IL-8, BD-2, and BD-3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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