Thermo Fisher Scientific PREB Recombinant Rabbit Monoclonal Antibody (JE64-56)
PREB 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot과 IHC(P)에서 검증됨. 인간 시료에 반응하며, 단백질 A로 정제된 액상 형태. 단기 4℃, 장기 -20℃ 보관. 연구용으로 prolactin 조절 관련 연구에 적합.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:400 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JE64-56 |
| Immunogen | Recombinant protein within human PREB aa 81–230/417 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 0.05% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3092971 |
Product Specific Information
- Positive control: HepG2 cell lysates, human lymph nodes tissue, human colon tissue
- Predicted band size: 45 kDa
- Subcellular Location: Endoplasmic reticulum membrane, Nucleus
Target Information
Prolactin (PRL) expression in the pituitary is limited to specific cells. Pit-1 is a pituitary-specific transcription factor that plays an important role in PRL expression, both in mature organisms and during development. The PRL promoter contains numerous Pit-1 binding sites implicated in both basal and kinase-mediated gene expression.
A novel protein, termed PREB (prolactin regulatory element binding protein), regulates PRL gene expression through the 1P site, though it contains no discernable DNA-binding motif. PREB is encoded by a single-copy gene in both mice and humans and exhibits nuclear accumulation in pituitary cells. Evidence suggests that PREB acts as a transcription factor assisting in PRL expression, alone or in concert with Pit-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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