Thermo Fisher Scientific CD42b Polyclonal Antibody
Thermo Fisher Scientific CD42b Polyclonal Antibody는 인간 CD42b 단백질을 인식하는 고품질 토끼 IgG 항체로, WB, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합합니다. 혈소판 활성 및 응집 관련 연구에 유용하며, 고순도 친화 크로마토그래피 정제 제품입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | - |
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
| Flow Cytometry (Flow) | 1:50–1:100 | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within Human CD42b aa 117–328 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2854693 |
Product Specific Information
Positive Control: Jurkat, human spleen tissue.
Target Information
CD42b is a platelet activation marker involved in coagulation and platelet aggregation. It interacts with extracellular matrix and adhesion molecules. CD42b expression and activation are regulated by VEGF and PDGF. Together with GPIb beta, GPIX, and GPV, CD42b forms the GPIb-IX-V receptor complex, essential for platelet-rich thrombus formation by tethering platelets to thrombogenic surfaces. It binds to von Willebrand factor (VWF), thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1, and P-selectin. The extracellular domain contributes to metastasis. CD42b antigen is expressed on platelets and megakaryocytes in bone marrow. Mutations in CD42b are associated with Bernard-Soulier syndrome and platelet-type von Willebrand disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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