Thermo Fisher Scientific CACNG1 Polyclonal Antibody
CACNG1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot, IHC, ICC/IF, Flow cytometry에 적합합니다. 사람 및 생쥐 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within mouse CACNG1 (aa 13–62) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2854694 |
Product Specific Information
Positive Control: Human skeletal muscle tissue, mouse skeletal muscle tissue, rat skeletal muscle tissue, SH-SY-5Y cells.
Target Information
Voltage-dependent calcium channels are essential for neurotransmitter release. L-type voltage-dependent calcium channels consist of four subunits: alpha1, beta, gamma, and alpha2 delta. The gamma subunit, CACNG1 (also known as CACNLG), is a 222 amino acid multi-pass membrane protein belonging to the PMP-22/EMP/MP20 family and is expressed in skeletal muscle. It acts as a subunit of the dihydropyridine (DHP)-sensitive calcium channel and may play a role in excitation-contraction coupling. CACNG1 is considered a novel marker for malignant hyperthermia susceptibility (MHS), an autosomal dominant skeletal muscle disorder triggered by certain anesthetics and muscle relaxants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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