Thermo Fisher Scientific p21 Recombinant Rabbit Monoclonal Antibody (4Z1H9)
p21 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ELISA에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 세포 주기 조절 및 DNA 손상 반응 연구에 유용합니다. 고순도 정제 및 안정한 액상 형태로 제공됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:800 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4Z1H9 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–164 of human CDKN1A/p21CIP1 (NP_000380.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2911821 |
Product Specific Information
- Positive test controls: MCF7, HeLa, 293T
- Localization: Cytoplasm, Nucleus
Immunogen sequence:
MSEPAGDVRQ NPCGSKACRR LFGPVDSEQL SRDCDALMAG CIQEARERWN FDFVTETPLE GDFAWERVRG LGLPKLYLPT GPRRGRDELG GGRRPGTSPA LLQGTAEEDH VDLSLSCTLV PRSGEQAEGS PGGPGDSQGR KRRQTSMTDF YHSKRRLIFS KRKP
Target Information
Protein p21 is a tumor suppressor protein that inhibits Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. It plays a key role in the cellular response to genotoxic stress and is a major transcriptional target of p53.
In the nucleus, p21 binds and inhibits Cdk1 and Cdk2, blocking the transition from G1 to S phase or G2 to mitosis after DNA damage, allowing DNA repair.
In the cytoplasm, p21 has an anti-apoptotic effect by binding to and inhibiting caspase 3, ASK1, and JNK. p21 exhibits dual roles in carcinogenesis, acting as both a tumor suppressor and oncogene depending on context.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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