Thermo Fisher Scientific S100B Recombinant Rabbit Monoclonal Antibody (4V8R6)
S100B 단백질을 인식하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체(4V8R6). WB, IHC, ICC/IF, ELISA 등 다양한 응용 가능. 높은 특이성과 재현성 제공. 인간, 마우스, 랫트 시료에 반응하며 연구용으로 적합.
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:4,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:800 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4V8R6 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–92 of human S100B (NP_006263.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2911824 |
Product Specific Information
Positive test controls include: Rat testis, Rat brain, A375, Mouse brain.
The target is usually found in the following locations: Cytoplasm, Nucleus.
Immunogen sequence:
MSELEKAMVA LIDVFHQYSG REGDKHKLKK SELKELINNE LSHFLEEIKE QEVVDKVMET LDNDGDGECD FQEFMAFVAM VTTACHEFFE HE
Target Information
S100B is a member of the S100 family of proteins containing two EF-hand calcium-binding motifs.
S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells and are involved in regulating cellular processes such as cell cycle progression and differentiation.
S100B may function in:
- Neurite extension
- Proliferation of melanoma cells
- Stimulation of Ca²⁺ fluxes
- Inhibition of PKC-mediated phosphorylation
- Astrocytosis and axonal proliferation
- Inhibition of microtubule assembly
Chromosomal rearrangements and altered expression of this gene have been implicated in multiple diseases, including Alzheimer’s disease, Down’s syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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