Thermo Fisher Scientific Diazepam Binding Inhibitor Polyclonal Antibody
Diazepam Binding Inhibitor(DBI)에 특이적인 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 응용에 적합. Human, Mouse, Rat에 반응하며 Affinity chromatography로 정제됨. 1 mg/mL 농도, PBS/glycerol buffer에 보관하며 -20°C에서 안정적으로 저장 가능.
- 카탈로그번호
- PA5102751
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DBI (Accession P07108), corresponding to amino acid residues P20–A70 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852142 |
Product Specific Information
Antibody detects endogenous levels of total DBI.
Target Information
This gene encodes diazepam binding inhibitor, a protein regulated by hormones and involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses.
The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters.
Diazepam binding inhibitor also mediates feedback regulation of pancreatic secretion and postprandial release of cholecystokinin, and acts as a mediator in corticotropin-dependent adrenal steroidogenesis.
Three pseudogenes located on chromosomes 6, 8, and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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