Thermo Fisher Scientific GFR alpha-1 Polyclonal Antibody
GFRA1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin)에서 검증됨. 인간, 마우스, 랫트 반응성. 고순도 친화 크로마토그래피 정제, PBS/glycerol 버퍼에 보관. 연구용 전용 제품.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GFRA1 (Accession P56159), corresponding to amino acid residues S349–Q399 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852143 |
Product Specific Information
This antibody detects endogenous levels of total GFRA1.
Target Information
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nervous system. Physiological responses to GDNF require the presence of a glycosylphosphatidylinositol-linked protein GDNFRα, a cell surface receptor for GDNF.
GDNFRα (also known as Ret ligand 1, TGF-β-related neurotrophic factor receptor 1, or GFR-α-1) binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK).
Together, GDNF, GFR-α, and Ret PTK form a complex that transduces GDNF signaling and mediates its function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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